Electronic invoicing in healthcare: do you know what it involves and which companies it affects?

Mar 30, 2025 | Electronic invoicing

The electronic invoicing is a reality, and there is no industry that cannot benefit from it. Likewise, in the healthcare sector, it is already an indispensable process and tool. In fact, it is installed in hospitals, clinics, and other institutions in the sector. The truth is that, in addition to helping to comply with tax laws, it brings business improvements: operational efficiency, lower administrative costs, data security, etc. At easyap, we are taking advantage of this article to detail everything that electronic invoicing in healthcare, how it is implemented, the regulations that govern it, and how to optimize it to improve financial management.

Why is electronic invoicing important in healthcare?

The digitization of administrative processes in healthcare is much more than just a trend. Today, it has become a necessity. In fact, we already warned of the role that electronic invoicing would play in the healthcare sector , and now it is beginning to become a reality.

The volume of transactions between healthcare providers, insurers, and patients is enormous. Therefore, in the digital age, it is essential to have an efficient billing system. To be specific, among the main reasons for adopting electronic invoicing in healthcare, we highlight the following:

  • Lower costs. Eliminate expenses related to printing, paper, storage, and shipping of physical documents.
  • Greater transparency and traceability. It offers detailed control of invoices, reducing errors and fraud.
  • Regulatory compliance. Helps you comply with the tax regulations of each country. Spain, with the arrival of mandatory electronic invoicing, attests to this. 
  • Automation and efficiency. Reduces administrative burden for companies in the sector and speeds up payment times.
  • Accessibility and security. Documents are stored in the cloud with secure backup and can be accessed in real time from multiple devices and locations.

How does the electronic invoicing process work in the healthcare sector?

In terms of how it works, electronic invoicing in healthcare institutions follows a structured process that guarantees the validity and security of each invoice or document. 

1. Invoice generation

  • The invoice is created in XML format, following the UBL V 2.1 standard.
  • This includes billing information required by law. That is, issuer, recipient, description of the services provided, and the corresponding amounts.

2. Digital signature

  • The digital invoice must have an electronic signature that guarantees its authenticity and integrity.

3. Numbering assignment

  • A consecutive number authorized by the country's tax authority is assigned. 

4. Submission and validation

  • The invoice is sent to the recipient (hospital, insurance company, patient, center, etc.) and recorded in the tax system for validation.

5. Storage and custody

  • The documentation must be stored digitally for the period stipulated by the regulations in force in each country. 

Requirements for electronic invoicing in the healthcare sector

Specifically, each country has its own regulations for electronic invoicing in healthcare institutions. In this regard, Spain conforms to the legal framework dictated by the European Union. However, each nation then enacts its own regulations within that common framework with its own deadlines.

Similarly, in the EU, electronic invoicing in healthcare is regulated by Directive 2014/55/EU. This law establishes the mandatory use of standard electronic formats for invoices for transactions with the public sector.

In Spain, we are taking advantage of this regulation and other national laws such as the Create and Grow Law or the electronic invoicing regulations, all businesses in the healthcare sector must meet the following requirements:

  • Facturae format. The invoice must be generated in XML format Facturae format.
  • Use of Cl@ve Signature or digital certificate. This is necessary to guarantee the authenticity and integrity of the document.
  • Referral to FACe (General Entry Point for Electronic Invoices). This step is necessary for transactions with public entities. In any case, if you have any questions, at easyap we explain how to issue FACE invoices.
  • Secure storage. In Spain, with specific exceptions, this storage must be for at least 5 years.

In turn, other countries such as France, Italy and Germany have also implemented similar systems for electronic invoicing, and not just for the healthcare sector. In other words, they require the use of official platforms to validate electronic invoices. And in a few years, it will be a reality and a legal requirement for the entire EU. 

For all these reasons, healthcare companies across Europe will need to ensure they have an electronic invoicing system that allows for interoperability with other financial and accounting systems.

When is it mandatory to issue an electronic invoice in healthcare?

However, at present, the mandatory use of electronic invoicing in healthcare still varies from one region to another. In Spain, within the healthcare sector, it is mandatory in the following cases:

  • Hospitals, clinics, and medical centers that bill government entities or insurance companies.
  • Pharmacies and laboratories that issue electronic receipts for the sale of medicines and the provision of services.
  • Independent healthcare professionals who exceed certain income thresholds.
  • Medical supply companies that work with both the public and private sectors.

Even so, we insist that European and national regulations and trends indicate that electronic invoicing will soon be mandatory for all transactions. 

Tips for efficiently integrating electronic invoicing in healthcare institutions

When it comes to implementation, electronic invoicing in healthcare or any other sector is not easy. Above all, because it involves processes that are influenced by technology, and because employees have to adapt to change. 

At easyap, we know what we're talking about, as we've been helping organizations of all kinds take the plunge for decades. Therefore, for the successful implementation of electronic invoicing, we recommend:

  • Choose software that complies with current regulations.
  • Train administrative staff in the use of the billing system.
  • Automate the issuance and receipt of invoices to avoid errors and delays.
  • Ensure integration with your ERP and accounting systems.
  • Conduct regular audits to find possible errors in the system.
  • Keep secure digital copies in the cloud that guarantee access to and backup of information.

How does easyap help optimize electronic invoicing in healthcare?

Furthermore, at easyap we don't just advise you. We develop solutions to automate electronic invoicing ourselves. Software that optimizes the administrative processes of companies and businesses in the healthcare sector and any other industry. 

Thanks to our use of the most advanced technology, at easyap we reach out to all types of companies in the healthcare sector: hospitals, clinics, insurance companies... With us, you can: 

  • Comply with national and international tax laws national and international tax laws without difficulty.
  • Integrate electronic invoicing with your accounting systems and ERPs.
  • Streamline invoice receipt and validation.
  • Securing information and data with cloud storage.
  • Reduce operating costs and minimize human error in the process.

With easyap, any business or healthcare institution can improve its financial management, speed up payments, and comply with applicable laws.

In summary, electronic invoicing in healthcare improves the administrative and financial management of hospitals, clinics, and insurance companies. Efficiency, economic improvement, legal compliance, data security... If you want to take the plunge and implement a powerful, secure, and effective solution to manage electronic invoicing in your healthcare institution, easyap is the best solution. Contact us and we will demonstrate it to you. 

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